Functionalized Magnetic Nanoparticles for Selective Targeting of Cells

نویسندگان

  • Mohammed I. Shukoor
  • Filipe Natalio
  • Muhammad Nawaz Tahir
  • Thomas Schladt
  • Kerstin Schneider
  • Mathias Wiens
  • Heinz-C. Schröder
  • Werner E. G. Müller
  • Wolfgang Tremel
چکیده

Magnetic metal oxide nanoparticles were conjugated to single stranded DNA (ssDNA), and Cytosin-phosphatidyl-Guanosin oligonucleotide (CpG ODN) to detect and activate Toll-like (TLR9) receptors in cells and to follow nanoparticle cellular trafficking by different ways of imaging while at the same time serving as a drug carrier system. By virtue of their magnetic properties these nanoparticles may serve as vehicles for the transport of target molecules into cells, while the fluorescent target ligand allows optical detection simultaneously.

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تاریخ انتشار 2009